Cancer Translational Medicine

Case Report | Open Access

Vol.9 (2023) | Issue-3 | Page No: 138-149


Tumor Regression after COVID-19 Infection in Metastatic Adrenocortical Carcinoma Treated with Immune Checkpoint Blockade: A Case Report

Qiaoxin Lin1, Bin Liang1, Yangyang Li2, Ling Tian3*, Dianna Gu1*


1 Department of Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

2 Department of Clinical Pathology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

3 Department of Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

* Corresponding Author


Address for correspondence:

Ling Tian, Department of Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University, No. 241 Huaihai West Road, Xuhui District, Shanghai 200030, China. E-mail:

Dianna Gu, Department of Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Town, Ouhai District, Wenzhou 325000, Zhejiang, China. E-mail:

Important Dates  

Date of Submission:   28-Jul-2023

Date of Acceptance:   13-Sep-2023

Date of Publication:   09-Oct-2023


The impact of the COVID-19 global pandemic on human health goes far beyond the reported deaths. Individuals suffering from cancers are more susceptible to infection and have high rates of hospitalization and death. However, a fraction of cancer patients might benefit from the COVID-19 infection. Herein, we report a case of adrenocortical carcinoma treated with immune checkpoint blockade (ICB) recovered from COVID-19 infection and was found to have subsided liver and lung metastases. The patient who was previously resistant to ICB therapy and whose tumors continued to progress showed significant tumor regression after COVID-19 infection and recovery.


Keywords: COVID-19 infection; Immune checkpoint blockade; PD-1 inhibitor; Adrenocortical carcinoma; Tumor regression


Since its outbreak in 2019, the COVID-19 global pandemic has been profoundly affecting human health, causing far more deaths than ever reported. Individuals suffering from a variety of cancers are particularly vulnerable to COVID-19 infection and have higher rates of hospitalization and death than others due to coexisting chronic disease, poor overall health, and a systemic immunosuppression state resulting from cancer or anticancer treatment.[1] It has been reported that immune cells, such as Teffs (T effector cells), Tregs (T regulatory cells), NKs (natural killer cells), and APCs (antigen-presenting cells), exhibited uncontrolled functions in COVID-19.[2] However, the mechanisms that coordinate immune cell function and viral interaction remains unknown. As we know, severe COVID-19 is characterized by lymphopenia with a marked reduction in CD8+ T cells and upregulation of markers of exhaustion (e.g., PD-1). For anti-tumor agents, immunosuppressive cytotoxic chemotherapy is associated with worse outcomes. Nevertheless, it has been speculated that immune checkpoint blockades (ICBs) may have a beneficial association with COVID-19 outcomes.[3] 

In the past decade, cancer immunotherapy has made unprecedented progress and the most widely used immunotherapy agents are antibodies that block immunosuppressive receptors, such as CTLA-4 (cytotoxic T-lymphocyte antigen 4), PD-1 (programmed cell death protein 1) and PD-L1 (programmed death-ligand 1). Despite the proven clinical benefits of PD-1 or PD-L1-targeted therapy for a wide range of cancers, some patients may not be sensitive to ICBs or develop drug resistance after a period of medication.[4]

Adrenocortical carcinoma (ACC) is an extremely rare and aggressive malignancy, yet treatment options are limited. Systemic therapy, based on etoposide combined with doxorubicin plus mitotane, is the most effective treatment but possesses an unfavorable prognosis for advanced ACC.[5] The evidence of the implementation of ICBs in advanced ACC is limited.[6] Herein, we report a case of a patient with advanced ACC who developed resistance to ICB treatment and showed regression of metastatic lesions after COVID-19 infection and recovery.


On July 29, 2022, a 40-year-old female patient was admitted to our hospital due to gastric distention and pain. Besides, the patient also had other clinical manifestations such as a masculine voice, facial acne, hirsutism syndrome, and persistent menstrual irregularities. An abdominal computed tomography (CT) scan showed a large lesion in the liver [Figure 1A], and a chest CT scan revealed numerous scattered nodules, which were suspected to be metastatic lesions [Figure 1B]. And yet, no suspicious lesions were detected by CT scan in the adrenal cortex then. Subsequently, the patient underwent an ultrasound-guided liver aspiration biopsy. The pathological findings were reported as adrenocortical carcinoma with liver metastasis on August 15, 2022 [Figure 2]. To confirm the diagnosis, the patient also underwent a lung biopsy in Shanghai, and the biopsy specimen was sent for genomic RNA assay (Canhelp Genomics Co., Ltd) to detect the tumor origin, which was reported as an adrenal tumor [Supplementary Figure 1 & Supplementary Table 1]. The immunohistochemical analysis of PD-L1 expression in liver metastasis confirmed that tumor cell proportion score (TPS) and combined positive score (CPS) were both 0% [Supplementary Figure 2]. In addition, the next-generation sequencing (NGS) of the patient's liver metastatic samples revealed no detection of relevant genes affecting immune efficacy including ALK, EGFR, RET, KRAS, yet only one somatic mutation (AKAP8L-EWSR1(A1:E10) of EWSR1 gene) occurred, and the tumor mutational burden (TMB) was 0 [Supplementary Figure 3 & Supplementary Table 2, 3]. Thereupon, the patient was diagnosed with adrenocortical carcinoma stage IV with liver and lung metastases.

Figure 1.
Figure 1. Changes in liver and lung metastases before and after COVID-19 infection. (A-B) In July 2022, before diagnosed as adrenocortical carcinoma, the lesions in the liver measured 88.98 mm (A) and the metastatic nodules in the lung (B); (C-D) In October 2022, after diagnosed as adrenocortical carcinoma, the hepatic metastasis measured 85.51 mm (C) Progression of lung metastasis (D); (E-F) CT image acquired before COVID-19 infection, showed progressive increase in size of the liver lesion, measuring 92.35 mm (E) and increase in number and size of lung metastasis (F); (G-H) After COVID-19 infection, CT revealed tumor regression in the liver, measured 87.16 mm (G) and increase in number and size of lung metastasis (H).

Figure 2.
Figure 2. Clinical histopathology and immunohistochemistry. (A) Clinical histopathology revealed slightly scattered large nuclei, and heteromorphic cells (×100, ×200). (B) Immunohistochemistry showed that CD10, CK19, GPC-3, Hepatocyte, Arginase-1, CK, S-100, and EMA were negative, Inhibin, Melan-A, VIM, and Syn were positive, AFP was weakly positive, Ki67 was low (5%), and CD34 staining displayed vascularization and Reticulin indicated widened liver cords. DAB staining was used for immunohistochemistry (×400). CD10: cluster of differentiation 10; CD34: cluster of differentiation 34; CK19: cytokeratin 19; GPC-3: glypican-3; AFP: alpha-fetoprotein; CK: cytokeratin; S-100: S-100 protein; VIM: vimentin; EMA: epithelial membrane antigen; Syn: synaptophysin.

Then, in accordance with the patient’s preference, she was referred to the Shanghai Cancer Center of Fudan University and was advised mitotane treatment. However, after taking mitotane, the patient experienced severe malaise, vomiting, and other gastrointestinal reactions, hence the dosage was reduced. Later the patient returned to the First Affiliated Hospital of Wenzhou Medical University for further treatment. Based on some evidence of the potential benefit of immunotherapy in ACC7 and the poor performance status of the patient, the doctors in the First Affiliated Hospital of Wenzhou Medical University adjusted the treatment regimen to a modified dosage of mitotane plus pembrolizumab 200mg every 3 weeks using (q3w) in October 2022. However, she developed some more significant symptoms, including dyspnea and more pronounced abdominal discomfort. The CT evaluation showed her lung metastases continued to increase in both number and size. Furthermore, the patient's liver metastases initially showed transient shrinkage followed by enlargement [Figure 1C-1F], suggesting resistance to PD-1 blockade.

On December 23, 2022, the patient was infected with COVID-19. The patient underwent two positive rapid antigenic tests at home, instead of going to the hospital for COVID-19 nucleic acid test. During her infection, the patient developed a fever for one day and mild chest tightness for one week. The patient was administered non-steroidal anti-inflammatory drugs to relieve symptoms. One week later, she tested negative for COVID-19 antigen.

On January 17, 2023, the patient returned to the First Affiliated Hospital of Wenzhou Medical University for evaluation of tumor development. Surprisingly, we found a considerable regression in the extent and size of her pulmonary metastases [Figure 1H], and a regression in the diameter of the liver metastases [Figure 1G]. We then tested the patient's hormone levels and found that the adrenocorticotropic hormone (ACTH), prolactin, progesterone, and follicle-stimulating hormone (FSH) were elevated after COVID-19 infection [Figure 3A-3D], while testosterone, cortisol, luteinizing hormone (LH) and estradiol were decreased [Figure 3E-3H]. At follow-up, the patient began to experience recurrent hyponatremia, hyperkalemia, and other therapeutic drug response reactions that never occurred during the rapid progression of the disease. In terms of clinical presentation, her dyspnea and abdominal pain have improved. She will continue to use mitotane in combination with pembrolizumab as a treatment regimen. 

It should be pointed out that, prior to diagnosis and medication, the patient had visited the First Affiliated Hospital in November 2021 for subxiphoid pain. At that time, abdominal CT showed a large occupancy in the right lobe of the liver, and then an ultrasound-guided liver puncture was performed in Shanghai. Due to the rarity of ACC and the lack of specific tumor biomarkers, the patient was once diagnosed with hepatocellular carcinoma (HCC) and underwent a series of HCC treatments. A timeline that summarizes these events is shown in Figure 3I.

Figure 3.
Figure 3. Patient hormone curves and treatment timeline. (A) ACTH levels in patient increased after COVID-19 infection; (B) Prolactin levels in patient increased after COVID-19 infection; (C) Progesterone levels first decreased and then increased after COVID-19 infection; (D) FSH levels increased after COVID-19 infection; (E) Testosterone levels in patient decreased to the normal range after COVID-19 infection; (F) Cortisol levels in patient continued to be decreased after COVID-19 infection; (G) LH levels in patients decreased after COVID-19 infection; (H) Patient had higher estradiol levels than in May; (I) The timeline of events.


It is generally accepted that people with cancer are more likely to suffer from severe disease and have a higher mortality rate compared with non-cancer patients infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).[1],[6] However, a retrospective cohort study revealed that there was no difference in mortality between cancer and noncancer patients, and the increased risk of mortality was associated with obesity and active smoking.[8] Some scholars even believe that a second SARS-CoV-2 infection seems to be beneficial in controlling tumor progression.[9] Furthermore, instances of spontaneous tumor regression have been documented in certain tumors in conjunction with COVID-19 infection.[10] However, a dysfunctional status of T cells and abnormal PD-1/PD-L1 immune checkpoint axis were observed in patients who recovered from COVID-19.[11] So far, the impact of SARS-CoV-2 infection on the efficacy of PD-1 inhibitor in patients with cancer is yet unknown.

This is the first report, to our knowledge, describing a patient with advanced ACC treated with mitotane in combination with immunotherapy. The patient recovered from COVID-19 and subsequently experienced a significant reduction of lung and liver metastases. Prior to COVID-19 infection, the patient with negative expression of PD-L1 in tumor tissue had presented resistance to mitotane in combination with anti-PD-1. Due to the cytotoxic effects of mitotane on mitochondria in adrenal cortical cells,[12] the efficacy of the treatment was substantially improved after COVID-19 infection, suggesting that COVID-19 infection could increase the sensitivity of anti-PD-1.

The upregulation of immune checkpoints, such as PD-1, PD-L1, PD-L2 (Programmed Death-Ligand 2), CTLA-4, TIM-3 (T-cell Immunoglobulin and Mucin Domain 3), TIGIT (T-cell Immunoreceptor with Ig and ITIM Domains), etc, on T cells in patients with COVID-19, is one of the most manifestations leading to T-cell exhaustion, contributing to worse clinical outcomes.[13] Blockade of PD-1 signaling in the exhausted T cells isolated from COVID-19 patients restored T cell functional response to COVID-19 and helped to control the infection.[11] Thus, the PD-1 blockade might alleviate the symptoms of this ACC patient infected with COVID-19, who just had a fever for one day and mild chest tightness for one week, contributing to the viral clearance.

Surprisingly, despite the fact that the lung and liver metastases were PD-1 inhibitor-resistant before SARS-CoV-2 infection, we noticed a considerable decline in metastases assessed by CT post-infection. Currently, we know that multiple factors, such as tumor immunogenicity, T cell function, PD-L1 expression, tumor microenvironment, and so on, have been found to be associated with the efficacy of PD-1/PD-L1 blockade therapy.[14] It was reported that, during the acute phase of viral infection, an increase in the number of functional (not exhausted) PD-1+CD8+ T cells was detected in patients with SARS-CoV-2 infection.[15] However, the PD-1 receptor expression on the surface of CD8+ T cells is transient during the acute phase, which is distinguished from the sustained PD-1 expression on CD8+ T cells in patients with chronic infection or in cancer, rendering T-cell exhaustion or dysfunction.[16] In this case, PD-1 inhibitor seems to exert the effect at the crossroad between SARS-CoV-2 induced infection and ACC progression. We speculate that the increased PD-1 or PD-L1 expression during acute SARS-CoV-2 infection can restore T-cell function mediated by immune checkpoint blockade, and potentially reverse resistance in cancer patients with initial PD-L1 negative expression, as in the case reported above.

However, we should admit that severe SARS-CoV2 can induce systemic hyperinflammation and immune dysregulation, by increasing pro-inflammatory cytokines and chemokines,[17] which may create a microenvironment favorable to tumorigenesis and metastatic relapse.[18] Regrettably, due to the COVID-19 pandemic in the community in China, this patient opted to take home medication for symptomatic treatment, which left us with a lack of cytokine testing during her infection. Currently, the interactions among COVID-19, tumor cells, and the immune system are unknown. The effect of COVID-19-induced inflammation on tumor cells and their microenvironment needs to be investigated in detail, which is crucial for the evaluation of the potential long-term risks of COVID-19 in cancer patients, as well as for the selection of safe and effective antitumor immunotherapeutic regimens.

In conclusion, there is not enough data about tumor reduction in patients under ICB therapy after infected with COVID-19, but we would like to share this case. Based on the currently available data, we cannot make recommendations regarding the contribution of SARS-CoV-2 infection on ICB therapy, and further studies are clearly needed. Therefore, we believe it is important to share our experiences.



This study was partially supported by the funding of the National Natural Science Foundation of China awarded to Ling Tian and Dianna Gu (No.82073203 to Ling Tian and No.81802328 to Dianna Gu).



The authors declare no conflicts of interest.



Written informed consent has been obtained from the patient to publish this paper.



Qiaoxin Lin contributed to the data curation and original draft preparation of the manuscript. Bin Liang played a significant role in conceptualizing the study. Yangyang Li contributed to the methodology development and provided valuable resources. Ling Tian's contributions encompassed reviewing and providing supervision. Dianna Gu was involved in conceptualizing the study and reviewing it. All authors contributed to the Manuscript editing and approved the version.



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Supplementary Figure 1.
Supplementary Figure 1. Detection of tumor tissue origin by genomic RNA assay. (A) Pathological section of metastatic pulmonary tumor, Hematoxylin/eosin (HE) staining of tumor samples was performed following standard procedures; (B) Gene expression profiling showed a 79.8% probability that the tumor tissue originated from an adrenal tumor; (C) Gene amplification curves of tumor samples.

Supplementary Figure 2.
Supplementary Figure 2. Immunohistochemical assay of PD-L1 expression in tumor tissues. (A) Immunohistochemical assay samples of PD-L1 expression for TPS index analysis; (B) immunohistochemical assay samples of PD-L1 expression for CPS index analysis.

Supplementary Figure 3.
Supplementary Figure 3. Distribution of gene copy number. The figure shows the distribution of gene copy number of all genes. Each dot represents a capture interval of the gene, and the colored ones highlights the genes that are focused on copy number variations. The horizontal axis represents the chromosome location of the gene, and the vertical axis represents the copy number calculated based on the NGS methodology (the red horizontal line represents the copy number of the normal gene).

Supplementary Table 1.
Supplementary Table 1. List of the detected genes related to tumor tissue origin

Supplementary Table 2.
Supplementary Table 2. Genetic testing of tumor samples

Supplementary Table 3.
Supplementary Table 3. Results of genetic tests for genes associated with important targeted drugs

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Jinrong Qu1, Xiang Li1, Lei Qin2, Lifeng Wang1, Junpeng Luo1, Jianwei Zhang1, Hongkai Zhang1, Jing Li1, Fei Sun3, Shouning Zhang1, Yanle Li1, Cuicui Liu1, Hailiang Li1

Extracting Breathing Signal Using Fourier Transform from Cine Magnetic Resonance Imaging

Jing Cai1,2, Yilin Liu2, Fangfang Yin1,2

Split End Family RNA Binding Proteins: Novel Tumor Suppressors Coupling Transcriptional Regulation with RNA Processing

Hairui Su1, Yanyan Liu2, Xinyang Zhao1

Thioredoxin-interacting Protein as a Common Regulation Target for Multiple Drugs in Clinical Therapy/Application

Pengxing  Zhang1, Xiaoling Pang2,3, Yanyang Tu1,4

Associations of Age and Chemotherapy with Late Skin and Subcutaneous Tissue Toxicity in a Hypofractionated Adjuvant Radiation Therapy Schedule in Post‑mastectomy Breast Cancer Patients

Mohammad Akram1, Ghufran Nahid1, Shahid Ali Siddiqui1, Ruquiya Afrose2

Monitoring of Disease Activity in Chronic Myeloid Leukemia‑chronic Phase Patients Treated with Indian Generic Veenat (NATCO) Imatinib Mesylate: A Tertiary Care Experience

Khushboo Dewan, Tathagat Chatterjee

Review of Cancer Immunotherapy: Application of Chimeric Antigen Receptor T Cells and Programmed Death 1/Programmed Death‑ligand 1 Antibodies

Tengfei Zhang1,2, Ling Cao1, Zhen Zhang1, Dongli Yue1, Yu Ping1, Hong Li1, Lan Huang1, Yi Zhang1,3,4,5

Systematic Review of MicroRNAs and its Therapeutic Potential in Glioma

Nan Liu1, Yanyang Tu2

The Involvement of p53‑miR‑34a‑CDK4 Signaling During the Development of Cervical Cancer

Huijun Zuo, Jieqi Xiong, Hongwei Chen, Sisun Liu, Qiaoying Gong, Fei Guo

Unusual Clinical Presentation of a Rare Type of Breast Malignancy: A Case Report and a Short Review of Literature

Nadeesha J. Nawarathna1, Navam R. Kumarasinghe1, Palitha Rathnayake2,
Ranjith J. K. Seneviratne1

Sweet’s Syndrome in Acute Lymphoblastic Leukemia with t (9:22)

Khushboo Dewan, Shailaja Shukla

Analysis of the Correlationship between Prostate Specific Antigen Related Variables and Risk Factor in Patients with Prostate Carcinoma

Daoyuan Wang1, Tiejun Yang2, Yongqiang Zou1, Xinqiang Yang1

Recent Progress in Genetic and Epigenetic Profile of Diffuse Gastric Cancer

Zhengxi He1, Bin Li1,2

Strategies for Management of Spinal Metastases: A Comprehensive Review

Zhantao Deng, Bin Xu, Jiewen Jin, Jianning Zhao, Haidong Xu

Application and Perspectives of Traditional Chinese Medicine in the Treatment of Liver Cancer

Xia Mao, Yanqiong Zhang, Na Lin

Primary Hepatic Carcinoid Tumor: A Case Report and Literature Review

Yupeng Lei1, Hongxia Chen2, Pi Liu1, Xiaodong Zhou1

Expression Characteristics of miR‑10b in Nasopharyngeal Carcinoma

Gang Li, Yunteng Zhao, Jianqi Wang, Haoran Huang, Mengwen Zhang

An Update on Immunohistochemistry in Translational Cancer Research

Zonggao Shi, M. Sharon Stack

Promoter Methylated Tumor Suppressor Genes in Glioma

Yingduan Cheng1, Yanyang Tu2, Pei Liang3

Palliative Treatment of Malignant Pleural Effusion

Chenyang Liu1*, Qian Qian2*, Shen Geng1, Wenkui Sun1, Yi Shi1

Functional Perspective and Implications of Gene Expression by Noncoding RNAs

Xiaoshuang Yan1, Huanyu Xu2, Zhonghai Yan3

Expression of E3 Ubiquitin Ligases in Multiple Myeloma Patients after Treatment with the Proteasome Inhibitor Bortezomib

James Joseph Driscoll

miR‑505 Downregulates 6‑Phosphofructo‑2‑Kinase/ Fructose‑2,6‑Biphosphatase 4 to Promote Cell Death in Glioblastoma

Esther H. Chung, Hongwei Yang, Hongyan Xing, Rona S. Carroll, Mark D. Johnson

Utility of Fine Needle Aspiration Cytology in Diagnosing Bone Tumors

Sonal Mahajan1, Akash Arvind Saoji2, Anil Agrawal1

Histone H2A and H2B Deubiquitinase in Developmental Disease and Cancer

Demeng Chen1, Caifeng Dai2, Yizhou Jiang3

Genetic Characteristics of Glioblastoma: Clinical Implications of Heterogeneity

Qian Li1, Yanyang Tu1,2

Acute Lymphoblastic Leukemia with Normal Platelet Count

Khushboo Dewan, Kiran Agarwal

Galanin is a Novel Epigenetic Silenced Functional Tumor Suppressor in Renal Cell Carcinoma

Shengkun Sun1*, Axiang Xu1*, Guoqiang Yang1, Yingduan Cheng2


Selenium Dioxide Induced Apoptosis in Cervical Cancer Cells via Regulating Apoptosis-related Let-7a MicroRNA and Proteins

Sisun Liu1, Jieqi Xiong2, Ling Guo3, Min Xiu1,4, Feng He1,4, Yuanlei Lou5, Fei Guo6,7

Low Expression of Polo‑like Kinase 1 is Associated with Poor Prognosis in Liver Cancer

Weixia Li1, Kunpeng Liu1, Dechen Lin2, Xin Xu2, Haizhen Lu3, Xinyu Bi4, Mingrong Wang2

Extracorporeal Photopheresis for Steroid‑refractory Chronic Graft‑versus‑host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta‑Analysis

Runzhe Chen1, Baoan Chen1, Peter Dreger2, Michael Schmitt2, Anita Schmitt2

Glucans and Cancer: Historical Perspective

Petr Sima1, Luca Vannucci1, Vaclav Vetvicka2

Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer

Song Wu1, Andrew Fesler2, Jingfang Ju2

BCL2 Family, Mitochondrial Apoptosis, and Beyond

Haiming Dai1, X. Wei Meng2, Scott H. Kaufmann2

Quantum Dot‑based Immunohistochemistry for Pathological Applications

Li Zhou1, Jingzhe Yan2, Lingxia Tong3, Xuezhe Han4, Xuefeng Wu5, Peng Guo6

CD24 as a Molecular Marker in Ovarian Cancer: A Literature Review

Lu Huang1, Weiguo Lv2, Xiaofeng Zhao1

Etiological Trends in Oral Squamous Cell Carcinoma: A Retrospective Institutional Study

Varsha Salian, Chethana Dinakar, Pushparaja Shetty, Vidya Ajila

Effect of Irinotecan Combined with Cetuximab on Liver Function in Patients with Advanced Colorectal Cancer with Liver Metastases

Yan Liang1, Yang Li2, Xin Li3, Jianfu Zhao4

The Role of Precision Medicine in Pancreatic Cancer: Challenges for Targeted Therapy, Immune Modulating Treatment, Early Detection, and Less Invasive Operations

Khaled Kyle Wong1, Zhirong Qian2, Yi Le3

Targeting Signal Transducer and Activator of Transcription 3 for Colorectal Cancer Prevention and Treatment with Natural Products

Weidong Li1,2*, Cihui Chen3*, Zheng Liu2, Baojin Hua1

The Potential of Wnt Signaling Pathway in Cancer: A Focus on Breast Cancer

Mahnaz M. Kazi, Trupti I. Trivedi, Toral P. Kobawala, Nandita R. Ghosh

Imaging‑driven Digital Biomarkers

Enrico Capobianco

Target‑Matching Accuracy in Stereotactic Body Radiation Therapy of Lung Cancer: An Investigation Based on Four‑Dimensional Digital Human Phantom

Jing Cai1,2, Kate Turner2, Xiao Liang2, W. Paul Segars2,3, Chris R. Kelsey1, David Yoo1, Lei Ren1,2, Fang‑Fang Yin1,2

Downregulation of Death‑associated Protein Kinase 3 and Caspase‑3 Correlate to the Progression and Poor Prognosis of Gliomas

Ye Song, Tianshi Que, Hao Long, Xi’an Zhang, Luxiong Fang, Zhiyong Li, Songtao Qi

Hyaluronic Acid in Normal and Neoplastic Colorectal Tissue: Electrospray Ionization Mass Spectrometric and Fluor Metric Analysis

Ana Paula Cleto Marolla1, Jaques Waisberg2, Gabriela Tognini Saba2, Demétrius Eduardo Germini2, Maria Aparecida da Silva Pinhal1

Melanoma Antigen Gene Family in the Cancer Immunotherapy

Fengyu Zhu1, Yu Liang1, Demeng Chen2, Yang Li1

Combined Chronic Lymphocytic Leukemia and Pancreatic Neuroendocrine Carcinoma: A Collision Tumor Variation

Kaijun Huang1, Panagiotis J. Vlachostergios1, Wanhua Yang2, Rajeev L. Balmiki3

Antiproliferative and Apoptotic Effect of Pleurotus ostreatus on Human Mammary Carcinoma Cell Line (Michigan Cancer Foundation‑7)

Krishnamoorthy Deepalakshmi, Sankaran Mirunalini

Impact of Age on the Biochemical Failure and Androgen Suppression after Radical Prostatectomy for Prostate Cancer in Chilean Men

Nigel P. Murray1,2, Eduardo Reyes1,3, Nelson Orellana1, Cynthia Fuentealba1, Omar Jacob1

Carcinoma of Unknown Primary: 35 Years of a Single Institution’s Experience

Rana I. Mahmood1,2, Mohammed Aldehaim1,3, Fazal Hussain4, Tusneem A. Elhassan4,
Zubeir A. Khan5, Muhammad A. Memon6

Metformin in Ovarian Cancer Therapy: A Discussion

Yeling Ouyang1, Xi Chen2, Chunyun Zhang1, Vichitra Bunyamanop1, Jianfeng Guo3

The Progress in Molecular Biomarkers of Gliomas

Jing Qi1, Hongwei Yang2, Xin Wang2, Yanyang Tu1

Correlation between Paclitaxel Tc > 0.05 and its Therapeutic Efficacy and Severe Toxicities in Ovarian Cancer Patients

Shuyao Zhang1*, Muyin Sun2*, Yun Yuan3*, Miaojun Wang4*, Yuqi She1*, Li Zhou5, Congzhu Li5, Chen Chen1, Shengqi Zhang4

Identifying Gaps and Relative Opportunities for Discovering Membrane Proteomic Biomarkers of Triple‑negative Breast Cancer as a Translational Priority

Bhooma Venkatraman

The Molecular Mechanism and Regulatory Pathways of Cancer Stem Cells

Zhen Wang1, Hongwei Yang2, Xin Wang2, Liang Wang3, Yingduan Cheng4, Yongsheng Zhang5, Yanyang Tu1,2

Nanoparticle Drug Delivery Systems and Three‑dimensional Cell Cultures in Cancer Treatments and Research

Wenjin Shi1, Ding Weng2,3, Wanting Niu2,3

Choline Kinase Inhibitors Synergize with TRAIL in the Treatment of Colorectal Tumors and Overcomes TRAIL Resistance

Juan Carlos Lacal1, Ladislav Andera2

MicroRNA Regulating Metabolic Reprogramming in Tumor Cells: New Tumor Markers

Daniel Otero‑Albiol, Blanca Felipe‑Abrio

Biomarkers of Colorectal Cancer: A Genome‑wide Perspective

José M. Santos‑Pereira1, Sandra Muñoz‑Galván2

Nicotinamide Adenine Dinucleotide+ Metabolism Biomarkers in Malignant Gliomas

Manuel P. Jiménez‑García, Eva M. Verdugo‑Sivianes, Antonio Lucena‑Cacace

Patient-derived Xenografts as Models for Personalized Medicine Research in Cancer

Marco Perez, Lola Navas, Amancio Carnero

Genome‑wide Transcriptome Analysis of Prostate Cancer Tissue Identified Overexpression of Specific Members of the Human Endogenous Retrovirus‑K Family

Behnam Sayanjali1,2

Clinical Utility of Interleukin‑18 in Breast Cancer Patients: A Pilot Study

Reecha A. Parikh, Toral P. Kobawala, Trupti I. Trivedi, Mahnaz M. Kazi, Nandita R. Ghosh

Current and Future Systemic Treatment Options for Advanced Soft‑tissue Sarcoma beyond Anthracyclines and Ifosfamide

Nadia Hindi1,2, Javier Martin‑Broto1,2

The Genomic Organization and Function of IRX1 in Tumorigenesis and Development

Pengxing Zhang1, Hongwei Yang2, Xin Wang2, Liang Wang3, Yingduan Cheng4, Yongsheng Zhang5, Yanyang Tu1,2

Stem Cell‑based Approach in Diabetes and Pancreatic Cancer Management

Yi‑Zhou Jiang1, Demeng Chen2

Mutation Detection with a Liquid Biopsy 96 Mutation Assay in Cancer Patients and Healthy Donors

Aaron Yun Chen, Glenn D. Braunstein, Megan S. Anselmo, Jair A. Jaboni, Fernando Troy Viloria, Julie A. Neidich, Xiang Li, Anja Kammesheidt

The Application of Estrogen Receptor‑1 Mutations’ Detection through Circulating Tumor DNA in Breast Cancer

Binliang Liu, Yalan Yang, Zongbi Yi, Xiuwen Guan, Fei Ma

Circulating MicroRNAs and Long Noncoding RNAs: Liquid Biomarkers in Thoracic Cancers

Pablo Reclusa1, Anna Valentino1, Rafael Sirera1,2, Martin Frederik Dietrich3, Luis Estuardo Raez3, Christian Rolfo1

Exosomes Biology: Function and Clinical Implications in Lung Cancer

Martin Frederik Dietrich1, Christian Rolfo2, Pablo Reclusa2, Marco Giallombardo2, Anna Valentino2, Luis E. Raez1

Circulating Tumor DNA: A Potential Biomarker from Solid Tumors’ Monitor to Anticancer Therapies

Ting Chen1,2, Rongzhang He1,3, Xinglin Hu1,3,4, Weihao Luo1, Zheng Hu1,3, Jia Li1, Lili Duan1, Yali Xie1,2, Wenna Luo1,2, Tan Tan1,2, Di‑Xian Luo1,2

Novel Molecular Multilevel Targeted Antitumor Agents

Poonam Sonawane1, Young A. Choi1, Hetal Pandya2, Denise M. Herpai1, Izabela Fokt3,
Waldemar Priebe3, Waldemar Debinski1

Fish Oil and Prostate Cancer: Effects and Clinical Relevance

Pei Liang, Michael Gao Jr.

Stemness‑related Markers in Cancer

Wenxiu Zhao1, Yvonne Li2, Xun Zhang1

Autophagy Regulated by miRNAs in Colorectal Cancer Progression and Resistance

Andrew Fesler1, Hua Liu1, Ning Wu1,2, Fei Liu3, Peixue Ling3, Jingfang Ju1,3

Gastric Metastases Mimicking Primary Gastric Cancer: A Brief Literature Review

Simona Gurzu1,2,3, Marius Alexandru Beleaua1, Laura Banias2, Ioan Jung1

Possibility of Specific Expression of the Protein Toxins at the Tumor Site with Tumor‑specialized Promoter

Liyuan Zhou1,2, Yujun Li1,2, Changchen Hu3, Binquan Wang1,2

SKI‑178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

Jeremy A. Hengst1,2, Taryn E. Dick1,2, Arati Sharma1, Kenichiro Doi3, Shailaja Hegde4, Su‑Fern Tan5, Laura M. Geffert1,2, Todd E. Fox5, Arun K. Sharma1, Dhimant Desai1, Shantu Amin1, Mark Kester5, Thomas P. Loughran5, Robert F. Paulson4, David F. Claxton6, Hong‑Gang Wang3, Jong K. Yun1,2

A T‑cell Engager‑armed Oncolytic Vaccinia Virus to Target the Tumor Stroma

Feng Yu1, Bangxing Hong1, Xiao‑Tong Song1,2,3

Real‑world Experience with Abiraterone in Metastatic Castration‑resistant Prostate Cancer

Yasar Ahmed1, Nemer Osman1, Rizwan Sheikh2, Sarah Picardo1, Geoffrey Watson1

Combination of Interleukin‑11Rα Chimeric Antigen Receptor T‑cells and Programmed Death‑1 Blockade as an Approach to Targeting Osteosarcoma Cells In vitro

Hatel Rana Moonat, Gangxiong Huang, Pooja Dhupkar, Keri Schadler, Nancy Gordon,
Eugenie Kleinerman

Efficacy and Safety of Paclitaxel‑based Therapy and Nonpaclitaxel‑based Therapy in Advanced Gastric Cancer

Tongwei Wu, Xiao Yang, Min An, Wenqin Luo, Danxian Cai, Xiaolong Qi

Motion Estimation of the Liver Based on Deformable Image Registration: A Comparison Between Four‑Dimensional‑Computed Tomography and Four‑Dimensional-Magnetic Resonance Imaging

Xiao Liang1, Fang‑Fang Yin1,2, Yilin Liu1, Brian Czito2, Manisha Palta2, Mustafa Bashir3, Jing Cai1,2

A Feasibility Study of Applying Thermal Imaging to Assist Quality Assurance of High‑Dose Rate Brachytherapy

Xiaofeng Zhu1, Yu Lei1, Dandan Zheng1, Sicong Li1, Vivek Verma1, Mutian Zhang1, Qinghui Zhang1, Xiaoli Tang2, Jun Lian2, Sha X. Chang2, Haijun Song3, Sumin Zhou1, Charles A. Enke1

Role of Exosome microRNA in Breast Cancer

Wang Qu, Ma Fei, Binghe Xu

Recent Progress in Technological Improvement and Biomedical Applications of the Clustered Regularly Interspaced Short Palindromic Repeats/Cas System

Yanlan Li1,2*, Zheng Hu1*, Yufang Yin3, Rongzhang He1, Jian Hu1, Weihao Luo1, Jia Li1, Gebo Wen2, Li Xiao1, Kai Li1, Duanfang Liao4, Di-Xian Luo1,5

The Significance of Nuclear Factor‑Kappa B Signaling Pathway in Glioma: A Review

Xiaoshan Xu1, Hongwei Yang2, Xin Wang2, Yanyang Tu1

Markerless Four‑Dimensional‑Cone Beam Computed Tomography Projection‑Phase Sorting Using Prior Knowledge and Patient Motion Modeling: A Feasibility Study

Lei Zhang1,2, Yawei Zhang2, You Zhang1,2,3, Wendy B. Harris1,2, Fang‑Fang Yin1,2,4, Jing Cai1,4,5, Lei Ren1,2

The Producing Capabilities of Interferon‑g and Interleukin‑10 of Spleen Cells in Primary and Metastasized Oral Squamous Cell Carcinoma Cells-implanted Mice

Yasuka Azuma1,2, Masako Mizuno‑Kamiya3, Eiji Takayama1, Harumi Kawaki1, Toshihiro Inagaki4, Eiichi Chihara2, Yasunori Muramatsu5, Nobuo Kondoh1

“Eating” Cancer Cells by Blocking CD47 Signaling: Cancer Therapy by Targeting the Innate Immune Checkpoint

Yi‑Rong Xiang, Li Liu

Glycosylation is Involved in Malignant Properties of Cancer Cells

Kazunori Hamamura1, Koichi Furukawa2

Biomarkers in Molecular Epidemiology Study of Oral Squamous Cell Carcinoma in the Era of Precision Medicine

Qing‑Hao Zhu1*, Qing‑Chao Shang1*, Zhi‑Hao Hu1*, Yuan Liu2, Bo Li1, Bo Wang1, An‑Hui Wang1

I‑Kappa‑B Kinase‑epsilon Activates Nuclear Factor‑kappa B and STAT5B and Supports Glioblastoma Growth but Amlexanox Shows Little Therapeutic Potential in These Tumors

Nadège Dubois1, Sharon Berendsen2, Aurélie Henry1,2, Minh Nguyen1, Vincent Bours1,
Pierre Alain Robe1,2

Suppressive Effect of Mesenchymal Stromal Cells on Interferon‑g‑Producing Capability of Spleen Cells was Specifically Enhanced through Humoral Mediator(s) from Mouse Oral Squamous Cell Carcinoma Sq‑1979 Cells In Vitro

Toshihiro Inagaki1,2, Masako Mizuno‑Kamiya3, Eiji Takayama1, Harumi Kawaki1, Eiichi Chihara4, Yasunori Muramatsu5, Shinichiro Sumitomo5, Nobuo Kondoh1

An Interplay Between MicroRNA and SOX4 in the Regulation of Epithelial–Mesenchymal Transition and Cancer Progression

Anjali Geethadevi1, Ansul Sharma2, Manish Kumar Sharma3, Deepak Parashar1

MicroRNAs Differentially Expressed in Prostate Cancer of African‑American and European‑American Men

Ernest K. Amankwah

The Role of Reactive Oxygen Species in Screening Anticancer Agents

Xiaohui Xu1, Zilong Dang2, Taoli Sun3, Shengping Zhang1, Hongyan Zhang1

Panobinostat and Its Combination with 3‑Deazaneplanocin‑A Induce Apoptosis and Inhibit In vitro Tumorigenesis and Metastasis in GOS‑3 Glioblastoma Cell Lines

Javier de la Rosa*, Alejandro Urdiciain*, Juan Jesús Aznar‑Morales, Bárbara Meléndez1,
Juan A. Rey2, Miguel A. Idoate3, Javier S. Castresana

Cancer Stem‑Like Cells Have Cisplatin Resistance and miR‑93 Regulate p21 Expression in Breast Cancer

Akiko Sasaki1, Yuko Tsunoda2, Kanji Furuya3, Hideto Oyamada1, Mayumi Tsuji1, Yuko Udaka1, Masahiro Hosonuma1, Haruna Shirako1, Nana Ichimura1, Yuji Kiuchi1

The Contribution of Hexokinase 2 in Glioma

Hui Liu1, Hongwei Yang2, Xin Wang3, Yanyang Tu1

The Mechanism of BMI1 in Regulating Cancer Stemness Maintenance, Metastasis, Chemo‑ and Radiation Resistance

Xiaoshan Xu, Zhen Wang, Nan Liu, Pengxing Zhang, Hui Liu, Jing Qi, Yanyang Tu

A Multisource Adaptive Magnetic Resonance Image Fusion Technique for Versatile Contrast Magnetic Resonance Imaging

Lei Zhang1,2, Fang‑Fang Yin1,2,3, Brittany Moore1,2, Silu Han1,2, Jing Cai1,2,4

Senescence and Cancer

Sulin Zeng1,2, Wen H. Shen2, Li Liu1

The “Wild”‑type Gastrointestinal Stromal Tumors: Heterogeneity on Molecule Characteristics and Clinical Features

Yanhua Mou1, Quan Wang1, Bin Li1,2

Retreatment with Cabazitaxel in a Long‑Surviving Patient with Castration‑Resistant Prostate Cancer and Visceral Metastasis

Raquel Luque Caro, Carmen Sánchez Toro, Lucia Ochoa Vallejo

Therapy‑Induced Histopathological Changes in Breast Cancers: The Changing Role of Pathology in Breast Cancer Diagnosis and Treatment

Shazima Sheereen1, Flora D. Lobo1, Waseemoddin Patel2, Shamama Sheereen3,
Abhishek Singh Nayyar4, Mubeen Khan5

Glioma Research in the Era of Medical Big Data

Feiyifan Wang1, Christopher J. Pirozzi2, Xuejun Li1

Transarterial Embolization for Hepatocellular Adenomas: Case Report and Literature Review

Jian‑Hong Zhong1,2, Kang Chen1, Bhavesh K. Ahir3, Qi Huang4, Ye Wu4, Cheng‑Cheng Liao1, Rong‑Rong Jia1, Bang‑De Xiang1,2, Le‑Qun Li1,2

Nicotinamide Phosphoribosyltransferase: Biology, Role in Cancer, and Novel Drug Target

Antonio Lucena‑Cacace1,2,3, Amancio Carnero1,2

Enhanced Anticancer Effect by Combination of Proteoglucan and Vitamin K3 on Bladder Cancer Cells

Michael Zhang, Kelvin Zheng, Muhammad Choudhury, John Phillips, Sensuke Konno

Molecular Insights Turning Game for Management of Ependymoma: A Review of Literature

Ajay Sasidharan, Rahul Krishnatry

IDH Gene Mutation in Glioma

Leping Liu1, Xuejun Li1,2

Challenges and Advances in the Management of Pediatric Intracranial Germ Cell Tumors: A Case Report and Literature Review

Gerard Cathal Millen1, Karen A. Manias1,2, Andrew C. Peet1,2, Jenny K. Adamski1

Assessing the Feasibility of Using Deformable Registration for Onboard Multimodality‑Based Target Localization in Radiation Therapy

Ge Ren1,2,3, Yawei Zhang1,2, Lei Ren1,2

Research Advancement in the Tumor Biomarker of Hepatocellular Carcinoma

Qing Du1, Xiaoying Ji2, Guangjing Yin3, Dengxian Wei3, Pengcheng Lin1, Yongchang Lu1,
Yugui Li3, Qiaohong Yang4, Shizhu Liu5, Jinliang Ku5, Wenbin Guan6, Yuanzhi Lu7

Novel Insights into the Role of Bacterial Gut Microbiota in Hepatocellular Carcinoma

Lei Zhang1, Guoyu Qiu2, Xiaohui Xu2, Yufeng Zhou3, Ruiming Chang4

Central Odontogenic Fibroma with Unusual Presenting Symptoms

Aanchal Tandon, Bharadwaj Bordoloi, Safia Siddiqui, Rohit Jaiswal

The Prognostic Role of Lactate in Patients Who Achieved Return of Spontaneous Circulation after Cardiac Arrest: A Systematic Review and Meta‑analysis

Dongni Ren1, Xin Wang2, Yanyang Tu1,2

Inhibitory Effect of Hyaluronidase‑4 in a Rat Spinal Cord Hemisection Model

Xipeng Wang1,2, Mitsuteru Yokoyama2, Ping Liu3

Research and Development of Anticancer Agents under the Guidance of Biomarkers

Xiaohui Xu1, Guoyu Qiu1, Lupeng Ji2, Ruiping Ma3, Zilong Dang4, Ruling Jia1, Bo Zhao1

Idiopathic Hypereosinophilic Syndrome and Disseminated Intravascular Coagulation

Mansoor C. Abdulla

Phosphorylation of BRCA1‑Associated Protein 1 as an Important Mechanism in the Evasion of Tumorigenesis: A Perspective

Guru Prasad Sharma1, Anjali Geethadevi2, Jyotsna Mishra3, G. Anupa4, Kapilesh Jadhav5,
K. S. Vikramdeo6, Deepak Parashar2

Progress in Diagnosis and Treatment of Mixed Adenoneuroendocrine Carcinoma of Biliary‑Pancreatic System

Ge Zengzheng1, Huang-Sheng Ling2, Ming-Feng Li2, Xu Xiaoyan1, Yao Kai1, Xu Tongzhen3,
Ge Zengyu4, Li Zhou5

Surface-Enhanced Raman Spectroscopy to Study the Biological Activity of Anticancer Agent

Guoyu Qiu1, Xiaohui Xu1, Lupeng Ji2, Ruiping Ma3, Zilong Dang4, Huan Yang5

Alzheimer’s Disease Susceptibility Genes in Malignant Breast Tumors

Steven Lehrer1, Peter H. Rheinstein2

OSMCC: An Online Survival Analysis Tool for Merkel Cell Carcinoma

Umair Ali Khan Saddozai1, Qiang Wang1, Xiaoxiao Sun1, Yifang Dang1, JiaJia Lv1,2, Junfang Xin1, Wan Zhu3, Yongqiang Li1, Xinying Ji1, Xiangqian Guo1

Protective Activity of Selenium against 5‑Fluorouracil‑Induced Nephrotoxicity in Rats

Elias Adikwu, Nelson Clemente Ebinyo, Beauty Tokoni Amgbare

Advances on the Components of Fibrinolytic System in Malignant Tumors

Zengzheng Ge1, Xiaoyan Xu1, Zengyu Ge2, Shaopeng Zhou3, Xiulin Li1, Kai Yao1, Lan Deng4

A Patient with Persistent Foot Swelling after Ankle Sprain: B‑Cell Lymphoblastic Lymphoma Mimicking Soft‑tissue Sarcoma

Crystal R. Montgomery‑Goecker1, Andrew A. Martin2, Charles F. Timmons3, Dinesh Rakheja3, Veena Rajaram3, Hung S. Luu3

Coenzyme Q10 and Resveratrol Abrogate Paclitaxel‑Induced Hepatotoxicity in Rats

Elias Adikwu, Nelson Clemente Ebinyo, Loritta Wasini Harris

Progress in Clinical Follow‑up Study of Dendritic Cells Combined with Cytokine‑Induced Killer for Stomach Cancer

Ling Wang1,2, Run Wan1,2, Cong Chen1,2, Ruiliang Su1,2, Yumin Li1,2

Supraclavicular Lymphadenopathy as the Initial Manifestation in Carcinoma of Cervix

Priyanka Priyaarshini1, Tapan Kumar Sahoo2

ABO Typing Error Resolution and Transfusion Support in a Case of an Acute Leukemia Patient Showing Loss of Antigen Expression

Debasish Mishra1, Gopal Krushna Ray1, Smita Mahapatra2, Pankaj Parida2

Protein Disulfide Isomerase A3: A Potential Regulatory Factor of Colon Epithelial Cells

Yang Li1, Zhenfan Huang2, Haiping Jiang3

Clinicopathological Association of p16 and its Impact on Outcome of Chemoradiation in Head‑and‑Neck Squamous Cell Cancer Patients in North‑East India

Srigopal Mohanty1, Yumkhaibam Sobita Devi2, Nithin Raj Daniel3, Dulasi Raman Ponna4,
Ph. Madhubala Devi5, Laishram Jaichand Singh2

Potential Inhibitor for 2019‑Novel Coronaviruses in Drug Development

Xiaohui Xu1, Zilong Dang2, Lei Zhang3, Lingxue Zhuang4, Wutang Jing5, Lupeng Ji6, Guoyu Qiu1

Best‑Match Blood Transfusion in Pediatric Patients with Mixed Autoantibodies

Debasish Mishra1, Dibyajyoti Sahoo1, Smita Mahapatra2, Ashutosh Panigrahi3

Characteristics and Outcome of Patients with Pheochromocytoma

Nadeema Rafiq1, Tauseef Nabi2, Sajad Ahmad Dar3, Shahnawaz Rasool4

Comparison of Histopathological Grading and Staging of Breast Cancer with p53‑Positive and Transforming Growth Factor‑Beta Receptor 2‑Negative Immunohistochemical Marker Expression Cases

Palash Kumar Mandal1, Anindya Adhikari2, Subir Biswas3, Amita Giri4, Arnab Gupta5,
Arindam Bhattacharya6

Chemical Compositions and Antiproliferative Effect of Essential Oil of Asafoetida on MCF7 Human Breast Cancer Cell Line and Female Wistar Rats

Seyyed Majid Bagheri1,2, Davood Javidmehr3, Mohammad Ghaffari1, Ehsan Ghoderti‑Shatori4

Cyclooxygenase‑2 Contributes to Mutant Epidermal Growth Factor Receptor Lung Tumorigenesis by Promoting an Immunosuppressive Environment

Mun Kyoung Kim1, Aidin Iravani2, Matthew K. Topham2,3

Potential role of CircMET as A Novel Diagnostic Biomarker of Papillary Thyroid Cancer

Yan Liu1,2,3,4#, Chen Cui1,2,3,4#, Jidong Liu1,2,3,4, Peng Lin1,2,3,4,Kai Liang1,2,3,4, Peng Su5, Xinguo Hou1,2,3,4, Chuan Wang1,2,3,4, Jinbo Liu1,2,3,4, Bo Chen6, Hong Lai1,2,3,4, Yujing Sun1,2,3,4* and Li Chen 1,2,3,4*

Cuproptosis-related Genes in Glioblastoma as Potential Therapeutic Targets

Zhiyu Xia1,2, Haotian Tian1, Lei Shu1,2, Guozhang Tang3, Zhenyu Han4, Yangchun Hu1*, Xingliang Dai1*

Cancer Diagnosis and Treatments by Porous Inorganic Nanocarriers

Jianfeng Xu1,2, Hanwen Zhang1,2, Xiaohui Song1,2, Yangong Zheng3, Qingning Li1,2,4*

Delayed (20 Years) post-surgical Esophageal Metastasis of Breast Cancer - A Case Report

Bowen Hu1#, Lingyu Du2#, Hongya Xie1, Jun Ma1, Yong Yang1*, Jie Tan2*

Subtyping of Undifferentiated Pleomorphic Sarcoma and Its Clinical Meaning

Umair Ali Khan Saddozai, Zhendong Lu, Fengling Wang, Muhammad Usman Akbar, Saadullah Khattak, Muhammad Badar, Nazeer Hussain Khan, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Guo

Construction of Glioma Prognosis Model and Exploration of Related Regulatory Mechanism of Model Gene

Suxia Hu, Abdusemer Reyimu, Wubi Zhou, Xiang Wang, Ying Zheng, Xia Chen, Weiqiang Li, Jingjing Dai

ESRP2 as a Non-independent Potential Biomarker-Current Progress in Tumors

Yuting Chen, Yuzhen Rao, Zhiyu Zeng, Jiajie Luo, Chengkuan Zhao, Shuyao Zhang

Resection of Bladder Tumors at the Ureteral Orifice Using a Hook Plasma Electrode: A Case Report

Jun Li, Ziyong Wang, Qilin Wang

Structural Characterization and Bioactivity for Lycium Barbarum Polysaccharides

Jinghua Qi1,2,  Hangping Chen3,Huaqing Lin2,4,Hongyuan Chen1,2,5* and Wen Rui2,3,5,6*

The Role of IL-22 in the Prevention of Inflammatory Bowel Disease and Liver Injury

Xingli Qi1,2, Huaqing Lin2,3, Wen Rui2,3,4,5 and Hongyuan Chen1,2,3

RBM15 and YTHDF3 as Positive Prognostic Predictors in ESCC: A Bioinformatic Analysis Based on The Cancer Genome Atlas (TCGA)

Yulou Luo1, Lan Chen2, Ximing Qu3, Na Yi3, Jihua Ran4, Yan Chen3,5*

Mining and Analysis of Adverse Drug Reaction Signals Induced by Anaplastic Lymphoma Kinase-Tyrosine Kinase Inhibitors Based on the FAERS Database

Xiumin Zhang1,2#, Xinyue Lin1,3#, Siman Su1,3#, Wei He3, Yuying Huang4, Chengkuan Zhao3, Xiaoshan Chen3, Jialin Zhong3, Chong Liu3, Wang Chen3, Chengcheng Xu3, Ping Yang5, Man Zhang5, Yanli Lei5*, Shuyao Zhang1,3*

Advancements in Immunotherapy for Advanced Gastric Cancer

Min Jiang1#, Rui Zheng1#, Ling Shao1, Ning Yao2, Zhengmao Lu1*

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